Hi, I too take 32mg serc 3 times per day and have done so for the past 4 years! Regarding the headaches, I've always suffered but haven't noticed a worsening during my high dose of serc. I have noticed however that over the 4 years of taking the serc, I've become really inflexible - something that I never had a problem with before taking this higher dose of histamine! Are you, or anybody else out there, able to comment on this?? I'd be very grateful to hear from you all :)